Endocrine Abstracts

The clinical course of pituitary adenoma is highly variable. Aggressive adenoma subtypes may require multimodal therapy with multiple operations. Even standard adenoma exhibit a relatively high long term recurrence rate and delayed intervention is often required. The indications for revision surgery in the endoscopic era are expanding for both functioning and non-functioning tumours, including access to the medial and lateral cavernous sinus and intracranial compartments. Alth...

Background: The clinical presentation of non-functioning pituitary adenomas (NFAs) can range from an incidental finding on imaging to pituitary hormone deficiencies and visual compromise.Objective: To assess the clinical presentation of patients who had undergone surgical resection of histologically proven NFAs.Methods: Patients presenting to the University Hospital of Wales, Cardiff, with non-functioning pituitary adenomas (histol...

Background: Serum prolactin levels at presentation can be useful in distinguishing between non-functioning pituitary macroadenomas and prolactinomas in order to guide appropriate therapy. Although thresholds have been suggested to distinguish between the two tumour-types, there remains some debate regarding discriminatory levels.Objective: To assess the baseline serum prolactin levels in a series of patients with histologically-proven non-functioning pit...